Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response.

Daks, Alexandra; Shuvalov, Oleg; Fedorova, Olga; Parfenyev, Sergey; Simon, Hans-Uwe; Barlev, Nickolai A (2023). Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response. International journal of biological sciences, 19(8), pp. 2304-2318. 10.7150/ijbs.83158

Preview

Text v19p2304.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence play an important role in the regulation of the cell's fate. ROS can cause irreversible damage to DNA and proteins resulting in cell death. Therefore, finely tuned regulatory mechanisms exist in evolutionarily diverse organisms that are aimed at the neutralization of ROS and its consequences with respect to cellular damage. The SET domain-containing lysine methyltransferase Set7/9 (KMT7, SETD7, SET7, SET9) post-translationally modifies several histones and non-histone proteins via monomethylation of the target lysines in a sequence-specific manner. In cellulo, the Set7/9-directed covalent modification of its substrates affects gene expression, cell cycle, energy metabolism, apoptosis, ROS, and DNA damage response. However, the in vivo role of Set7/9 remains enigmatic. In this review, we summarize the currently available information regarding the role of methyltransferase Set7/9 in the regulation of ROS-inducible molecular cascades in response to oxidative stress. We also highlight the in vivo importance of Set7/9 in ROS-related diseases.

Interest & Impact

Downloads

19 since deposited on 23 May 2023
16 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item