Hemphill, Andrew; Müller, Joachim (2023). Toxoplasma gondii infection: Novel emerging therapeutic targets. Expert opinion on therapeutic targets, 27(4-5), pp. 293-304. Taylor & Francis 10.1080/14728222.2023.2217353
Full text not available from this repository. (Request a copy)INTRODUCTION
Toxoplasmosis constitutes a challenge for public health, animal production and welfare. So far, only a limited panel of drugs has been marketed for clinical applications. Besides classical screening, the investigation of unique targets of the parasite may lead to the identification of novel drugs.
AREAS COVERED
Herein, the authors describe the methodology to identify novel drug targets in Toxoplasma gondii and review the literature with a focus on the last two decades.
EXPERT OPINION
During the last two decades, the investigation of essential proteins of T. gondii as potential drug targets has fostered the hope to identify novel compounds for the treatment of toxoplasmosis. Despite good efficacies in vitro, only a few classes of these compounds are effective in suitable rodent models, and none has cleared the hurdle to applications in humans. This shows that target-based drug discovery is in no way better than classical screening approaches. In both cases, off-target effects and adverse side effects in hosts must be considered. Proteomics-driven analyses of parasite- and host-derived proteins that physically bind drug candidates may constitute a suitable tool to characterize drug targets, irrespectively of the drug discovery methods.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Hemphill, Andrew, Müller, Heinz Joachim |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1744-7631 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
23 May 2023 09:15 |
Last Modified: |
14 Jun 2023 00:16 |
Publisher DOI: |
10.1080/14728222.2023.2217353 |
PubMed ID: |
37212443 |
Uncontrolled Keywords: |
Apicomplexa drug development host-parasite interactions proteomics |
URI: |
https://boris.unibe.ch/id/eprint/182810 |
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