Theileria-induced constitutive IKK activation is independent of functional Hsp90

Hermann, Pascal; Dobbelaere, Dirk, (2006). Theileria-induced constitutive IKK activation is independent of functional Hsp90. FEBS letters, 580(21), pp. 5023-8. Amsterdam: Elsevier 10.1016/j.febslet.2006.08.020

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The intracellular parasite Theileria induces uncontrolled proliferation and host cell transformation. Parasite-induced transformation is accompanied by constitutive activation of IkappaB kinase (IKK), resulting in permanently high levels of activated nuclear factor (NF)-kappaB. IKK activation pathways normally require heat shock protein 90 (Hsp90), a chaperone that regulates the stability and activity of signalling molecules and can be blocked by the benzoquinone ansamycin compound geldanamycin (GA). In Theileria-transformed cells, IkappaBalpha and p65 phosphorylation, NF-kappaB nuclear translocation and DNA binding activity are largely resistant to GA and also NF-kappaB-dependent reporter gene expression is only partly affected. Our findings indicate that parasite-induced IKK activity does not require functional Hsp90.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology

UniBE Contributor:

Hermann, Pascal and Dobbelaere, Dirk,

ISSN:

0014-5793

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

30 Jul 2014 14:39

Publisher DOI:

10.1016/j.febslet.2006.08.020

PubMed ID:

16938294

Web of Science ID:

000240693200008

URI:

https://boris.unibe.ch/id/eprint/18402 (FactScience: 456)

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