Hermann, Pascal; Dobbelaere, Dirk, (2006). Theileria-induced constitutive IKK activation is independent of functional Hsp90. FEBS letters, 580(21), pp. 5023-8. Amsterdam: Elsevier 10.1016/j.febslet.2006.08.020
Full text not available from this repository. (Request a copy)The intracellular parasite Theileria induces uncontrolled proliferation and host cell transformation. Parasite-induced transformation is accompanied by constitutive activation of IkappaB kinase (IKK), resulting in permanently high levels of activated nuclear factor (NF)-kappaB. IKK activation pathways normally require heat shock protein 90 (Hsp90), a chaperone that regulates the stability and activity of signalling molecules and can be blocked by the benzoquinone ansamycin compound geldanamycin (GA). In Theileria-transformed cells, IkappaBalpha and p65 phosphorylation, NF-kappaB nuclear translocation and DNA binding activity are largely resistant to GA and also NF-kappaB-dependent reporter gene expression is only partly affected. Our findings indicate that parasite-induced IKK activity does not require functional Hsp90.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology |
UniBE Contributor: |
Hermann, Pascal, Dobbelaere, Dirk, |
ISSN: |
0014-5793 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:44 |
Last Modified: |
05 Dec 2022 14:13 |
Publisher DOI: |
10.1016/j.febslet.2006.08.020 |
PubMed ID: |
16938294 |
Web of Science ID: |
000240693200008 |
URI: |
https://boris.unibe.ch/id/eprint/18402 (FactScience: 456) |
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