Theileria-induced leukocyte transformation

Dobbelaere, Dirk; Rottenberg, Sven (2003). Theileria-induced leukocyte transformation. Current opinion in microbiology, 6(4), pp. 377-382. London: Current Biology Ltd. 10.1016/S1369-5274(03)00085-7

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The intracellular protozoan parasites Theileria parva and T. annulata transform the cells they infect, inducing uncontrolled proliferation. This is not a trivial event as, in addition to permanently switching on the complex pathways that govern all steps of the cell cycle, the built-in apoptotic safety mechanisms that prevent 'illegitimate' cell replication also need to be inactivated. Recent experiments show that the NF-kappa B and phosphoinositide 3-kinase (PtdIns-3K) pathways are important participants in the transformation process. I kappa B kinase (IKK), a pivotal kinase complex in the NF-kappa B pathway, is recruited to the parasite surface where it becomes activated. The PtdIns-3K/Akt/PKB pathway is also constitutively activated in a parasite-dependent manner, but contrary to IKK, activation is probably not triggered by direct association with the parasite.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology

UniBE Contributor:

Dobbelaere, Dirk, and Rottenberg, Sven

Subjects:

600 Technology > 630 Agriculture

ISSN:

1369-5274

Publisher:

Current Biology Ltd.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:44

Last Modified:

15 Apr 2015 15:14

Publisher DOI:

10.1016/S1369-5274(03)00085-7

PubMed ID:

12941408

Web of Science ID:

000185173000011

URI:

https://boris.unibe.ch/id/eprint/18407 (FactScience: 461)

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