Theileria-induced leukocyte transformation

Dobbelaere, Dirk; Rottenberg, Sven (2003). Theileria-induced leukocyte transformation. Current opinion in microbiology, 6(4), pp. 377-382. London: Current Biology Ltd. 10.1016/S1369-5274(03)00085-7

Full text not available from this repository.

The intracellular protozoan parasites Theileria parva and T. annulata transform the cells they infect, inducing uncontrolled proliferation. This is not a trivial event as, in addition to permanently switching on the complex pathways that govern all steps of the cell cycle, the built-in apoptotic safety mechanisms that prevent 'illegitimate' cell replication also need to be inactivated. Recent experiments show that the NF-kappa B and phosphoinositide 3-kinase (PtdIns-3K) pathways are important participants in the transformation process. I kappa B kinase (IKK), a pivotal kinase complex in the NF-kappa B pathway, is recruited to the parasite surface where it becomes activated. The PtdIns-3K/Akt/PKB pathway is also constitutively activated in a parasite-dependent manner, but contrary to IKK, activation is probably not triggered by direct association with the parasite.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology
UniBE Contributor:	Dobbelaere, Dirk,, Rottenberg, Sven
Subjects:	600 Technology > 630 Agriculture
ISSN:	1369-5274
Publisher:	Current Biology Ltd.
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:44
Last Modified:	05 Dec 2022 14:13
Publisher DOI:	10.1016/S1369-5274(03)00085-7
PubMed ID:	12941408
Web of Science ID:	000185173000011
URI:	https://boris.unibe.ch/id/eprint/18407 (FactScience: 461)