Hammer, Nathalie; Legouis, David; Pasch, Andreas; Huber, Aurélie; Al-Qusairi, Lama; Martin, Pierre-Yves; de Seigneux, Sophie; Berchtold, Lena (2023). Calcification Propensity (T50) Predicts a Rapid Decline of Renal Function in Kidney Transplant Recipients. Journal of clinical medicine, 12(12) MDPI 10.3390/jcm12123965
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BACKGROUND
Serum creatinine level, proteinuria, and interstitial fibrosis are predictive of renal prognosis. Fractional excretion of phosphate (FEP)/FGF23 ratio, tubular reabsorption of phosphate (TRP), serum calcification propensity (T50), and Klotho's serum level are emerging as determinants of poor kidney outcomes in CKD patients. We aimed at analysing the use of FGF23, FEP/FGF23, TRP, T50, and Klotho in predicting the rapid decline of renal function in kidney allograft recipients.
METHODS
We included 103 kidney allograft recipients in a retrospective study with a prospective follow-up of 4 years. We analysed the predictive values of FGF23, FEP/FGF23, TRP, T50, and Klotho for a rapid decline of renal function defined as a drop of eGFR > 30%.
RESULTS
During a follow-up of 4 years, 23 patients displayed a rapid decline of renal function. Tertile of FGF23 (p value = 0.17), FEP/FGF23 (p value = 0.78), TRP (p value = 0.62) and Klotho (p value = 0.31) were not associated with an increased risk of rapid decline of renal function in kidney transplant recipients. The lower tertile of T50 was significantly associated with eGFR decline >30% with a hazard ratio of 3.86 (p = 0.048) and remained significant in multivariable analysis.
CONCLUSION
T50 showed a strong association with a rapid decline of renal function in kidney allograft patients. This study underlines its role as an independent biomarker of loss of kidney function. We found no association between other phosphocalcic markers, such as FGF23, FEP/FGF23, TRP and Klotho, with a rapid decline of renal function in kidney allograft recipients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Hammer, Nathalie |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Jun 2023 08:44 |
Last Modified: |
29 Jun 2023 08:53 |
Publisher DOI: |
10.3390/jcm12123965 |
PubMed ID: |
37373661 |
Uncontrolled Keywords: |
decline of renal function kidney transplant phosphocalcic markers prediction |
BORIS DOI: |
10.48350/184208 |
URI: |
https://boris.unibe.ch/id/eprint/184208 |
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