Sequence analysis of the porcine IFNAR1 and IFNGR2 genes

Leeb, Tosso; Dolle, K; Haase, Bianca (2006). Sequence analysis of the porcine IFNAR1 and IFNGR2 genes. Cytogenetic and genome research, 115(2), pp. 134-7. Basel: Karger 10.1159/000095233

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A porcine BAC clone harboring the tightly linked IFNAR1 and IFNGR2 genes was identified by comparative analysis of the publicly available porcine BAC end sequences. The complete 168,835 bp insert sequence of this clone was determined. Sequence comparisons of the genomic sequence with EST sequences from public databases were performed and allowed a detailed annotation of the IFNAR1 and IFNGR2 genes. The analyzed genes showed a conserved genomic organization with their known mammalian orthologs, however the sequence conservation of these genes across species was relatively low. In addition to the IFNAR1 and IFNGR2 genes, which were completely sequenced, the analyzed BAC clone also contained parts of an orphan gene encoding a putative transmembrane protein (TMEM50B). In contrast to the IFNAR1 and IFNGR2 genes the sequence conservation of the TMEM50B gene across different mammalian species was extremely high.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Leeb, Tosso and Haase, Bianca

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

1424-8581

Publisher:

Karger

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

16 Feb 2015 08:15

Publisher DOI:

10.1159/000095233

PubMed ID:

17065794

Web of Science ID:

000241664700006

URI:

https://boris.unibe.ch/id/eprint/18456 (FactScience: 599)

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