Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest.

Schmidbauer, Simon; Rylander, Christian; Cariou, Alain; Wise, Matt P; Thomas, Matthew; Keeble, Thomas R; Erlinge, David; Haenggi, Matthias; Wendel-Garcia, Pedro D; Bělohlávek, Jan; Morten Grejs, Anders; Nielsen, Niklas; Friberg, Hans; Dankiewicz, Josef (2023). Comparison of four clinical risk scores in comatose patients after out-of-hospital cardiac arrest. Resuscitation, 191, p. 109949. Elsevier 10.1016/j.resuscitation.2023.109949

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BACKGROUND AND AIMS

Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Management (TTM)-scores.

METHODS

This was a post-hoc analysis of the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. Missing data were handled by multiple imputation. The primary outcome was discriminatory performance assessed as the area under the receiver operating characteristics-curve (AUROC), with the outcome of interest being poor functional outcome or death (modified Rankin Scale 4-6) at 6 months after OHCA.

RESULTS

Data on functional outcome at 6 months were available for 1829 cases, which constituted the study population. The pooled AUROC for the MIRACLE2-score was 0.810 (95% CI 0.790 - 0.828), 0.835 (95% CI 0.816 - 0.852) for the TTM-score, 0.820 (95% CI 0.800 - 0.839) for the CAHP-score and 0.770 (95% CI 0.748 - 0.791) for the OHCA-score. At the cut-offs needed to achieve specificities >95%, sensitivities were <40 % for all four scoring systems.

CONCLUSIONS

The TTM-, MIRACLE2- and CAHP-scores are all capable of providing objective risk estimates accurate enough to be used as part of a holistic patient assessment after OHCA of a suspected cardiac origin. Due to its simplicity, the MIRACLE2-score could be a practical solution for both clinical application and risk stratification within trials.

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