Waskowski, Jan; Salvato, Sarah M; Müller, Martin; Hofer, Debora; van Regenmortel, Niels; Pfortmueller, Carmen A (2023). Choice of creep or maintenance fluid type and their impact on total daily ICU sodium burden in critically ill patients: A systematic review and meta-analysis. Journal of critical care, 78(154403), p. 154403. Elsevier 10.1016/j.jcrc.2023.154403
|
Text
1-s2.0-S0883944123001521-main.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
Purpose
Maintenance and hidden/creep fluids are a major source of fluid and sodium intake in intensive care unit (ICU) patients. Recent research indicates that low versus high sodium content maintenance fluids could decrease fluid and sodium burden. We conducted a systematic review (SR) with meta-analysis to summarize the impact of maintenance fluid choice on total daily sodium in ICU patients.
Materials and methods
Systematic literature search in Pubmed, Embase, the Cochrane Library and the Clinical Trials registry. Only controlled clinical trials were included. Exclusion criteria: trials on resuscitation fluids, performed in the emergency department only and in pediatric patients. Primary objective was the reduction in mean total sodium intake with low versus high sodium content maintenance/creep fluids.
Results
Five studies (1105 patients) were included. Heterogeneity was high.Risk of bias was moderate. Mean daily sodium reduction was 117 mmol (95%Confidence Interval [CI] -174; −59; p < 0.001) with low versus high sodium content maintenance/creep fluids. Incidence of hyperchloremia was lower (OR 0.26; 95%CI 0.1; 0.64) with low sodium. There were no differences in the incidences of hyper−/hyponatremia and fluid balances.
Conclusion
Using low sodium content maintenance/creep fluids substantially reduces daily sodium burden in adult ICU patients. Significant knowledge/research gaps exist regarding relevance and safety.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center |
UniBE Contributor: |
Waskowski, Jan, Salvato, Sarah Melanie, Müller, Martin (B), Pfortmüller, Carmen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0883-9441 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Anja Ebeling |
Date Deposited: |
31 Aug 2023 12:19 |
Last Modified: |
29 Oct 2023 02:22 |
Publisher DOI: |
10.1016/j.jcrc.2023.154403 |
BORIS DOI: |
10.48350/185940 |
URI: |
https://boris.unibe.ch/id/eprint/185940 |
Actions (login required)
 |
Edit item |