Schnaufer, Lukas; Gschaidmeier, Alisa; Heimgärtner, Magdalena; Driever, Pablo Hernáiz; Hauser, Till-Karsten; Wilke, Marko; Lidzba, Karen; Staudt, Martin (2024). Atypical language organization following perinatal infarctions of the left hemisphere is associated with structural changes in right-hemispheric grey matter. Developmental medicine and child neurology, 66(3), pp. 353-361. Wiley 10.1111/dmcn.15751
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AIM
To assess how atypical language organization after early left-hemispheric brain lesions affects grey matter in the contralesional hemisphere.
METHOD
This was a cross-sectional study with between-group comparisons of 14 patients (six female, 8-26 years) with perinatal left-hemispheric brain lesions (two arterial ischemic strokes, 11 periventricular haemorrhagic infarctions, one without classification) and 14 typically developing age-matched controls (TDC) with functional magnetic resonance imaging (fMRI) documented left-hemispheric language organization (six female, 8-28 years). MRI data were analysed with SPM12, CAT12, and custom scripts. Language lateralization indices were determined by fMRI within a prefrontal mask and right-hemispheric grey matter group differences by voxel-based morphometry (VBM).
RESULTS
FMRI revealed left-dominance in seven patients with typical language organization (TYP) and right-dominance in seven patients with atypical language organization (ATYP) of 14 patients. VBM analysis of all patients versus controls showed grey matter reductions in the middle temporal gyrus of patients. A comparison between the two patient subgroups revealed an increase of grey matter in the middle frontal gyrus in the ATYP group. Voxel-based regression analysis confirmed that grey matter increases in the middle frontal gyrus were correlated with atypical language organization.
INTERPRETATION
Compatible with a non-specific lesion effect, we found areas of grey matter reduction in patients as compared to TDC. The grey matter increase in the middle frontal gyrus seems to reflect a specific compensatory effect in patients with atypical language organization.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics |
UniBE Contributor: |
Lidzba, Karen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1469-8749 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Sep 2023 16:27 |
Last Modified: |
03 Feb 2024 00:12 |
Publisher DOI: |
10.1111/dmcn.15751 |
PubMed ID: |
37691416 |
BORIS DOI: |
10.48350/186229 |
URI: |
https://boris.unibe.ch/id/eprint/186229 |
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