Muttillo, Edoardo M; Felli, Eric; Felli, Emanuele; Muttillo, Edoardo M; Urade, Takeshi; Laracca, Giovanni G; Giannelli, Valerio; Famularo, Simone; Geny, Bernard; Ettorre, Giuseppe M; Rombouts, Krista; Pinzani, Massimo; Diana, Michele; Gracia-Sancho, Jordi (2023). Liver ischemia-reperfusion injury: From trigger loading to shot firing. official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 29(11), pp. 1226-1233. Wolters Kluwer 10.1097/LVT.0000000000000252
Full text not available from this repository.An ischemia-reperfusion injury (IRI) results from a prolonged ischemic insult followed by the restoration of blood perfusion, being a common cause of morbidity and mortality, especially in liver transplantation. At the maximum of the potential damage, IRI is characterized by 2 main phases. The first is the ischemic phase, where the hypoxia and vascular stasis induces cell damage and the accumulation of damage-associated molecular patterns and cytokines. The second is the reperfusion phase, where the local sterile inflammatory response driven by innate immunity leads to a massive cell death and impaired liver functionality. The ischemic time becomes crucial in patients with underlying pathophysiological conditions. It is possible to compare this process to a shooting gun, where the loading trigger is the ischemia period and the firing shot is the reperfusion phase. In this optic, this article aims at reviewing the main ischemic events following the phases of the surgical timeline, considering the consequent reperfusion damage.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Felli, Eric, Jordi, Gracia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1527-6473 |
Publisher: |
Wolters Kluwer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Sep 2023 09:15 |
Last Modified: |
20 Oct 2023 00:15 |
Publisher DOI: |
10.1097/LVT.0000000000000252 |
PubMed ID: |
37728488 |
URI: |
https://boris.unibe.ch/id/eprint/186441 |
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