Stark, Anselm W; Giannopoulos, Andreas A; Pugachev, Alexander; Shiri, Isaac; Haeberlin, Andreas; Räber, Lorenz; Obrist, Dominik; Gräni, Christoph (2023). Application of Patient-Specific Computational Fluid Dynamics in Anomalous Aortic Origin of Coronary Artery: A Systematic Review. Journal of cardiovascular development and disease, 10(9) MDPI 10.3390/jcdd10090384
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Anomalous aortic origin of a coronary artery (AAOCA) is a rare congenital heart condition with fixed and dynamic stenotic elements, potentially causing ischemia. Invasive coronary angiography under stress is the established method for assessing hemodynamics in AAOCA, yet it is costly, technically intricate, and uncomfortable. Computational fluid dynamics (CFD) simulations offer a noninvasive alternative for patient-specific hemodynamic analysis in AAOCA. This systematic review examines the role of CFD simulations in AAOCA, encompassing patient-specific modeling, noninvasive imaging-based boundary conditions, and flow characteristics. Screening articles using AAOCA and CFD-related terms prior to February 2023 yielded 19 publications, covering 370 patients. Over the past four years, 12 (63%) publications (259 patients) employed dedicated CFD models, whereas 7 (37%) publications (111 patients) used general-purpose CFD models. Dedicated CFD models were validated for fixed stenosis but lacked dynamic component representation. General-purpose CFD models exhibited variability and limitations, with fluid-solid interaction models showing promise. Interest in CFD modeling of AAOCA has surged recently, mainly utilizing dedicated models. However, these models inadequately replicate hemodynamics, necessitating novel CFD approaches to accurately simulate pathophysiological changes in AAOCA under stress conditions.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE) |
UniBE Contributor: |
Stark, Anselm Walter, Shiri Lord, Isaac, Häberlin, Andreas David Heinrich, Räber, Lorenz, Obrist, Dominik, Gräni, Christoph |
Subjects: |
600 Technology > 610 Medicine & health 600 Technology > 650 Management & public relations |
ISSN: |
2308-3425 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Sep 2023 14:48 |
Last Modified: |
28 Sep 2023 18:37 |
Publisher DOI: |
10.3390/jcdd10090384 |
PubMed ID: |
37754814 |
Uncontrolled Keywords: |
AAOCA CFD anomalous coronary artery computational fluid dynamics |
BORIS DOI: |
10.48350/186735 |
URI: |
https://boris.unibe.ch/id/eprint/186735 |
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