Reiners, Johanna Christina; Leopold, Laura; Hallebach, Vera; Sinske, Daniela; Meier, Philip; Amoroso, Mattia; Langgartner, Dominik; Reber, Stefan O; Knöll, Bernd (2023). Acute stress modulates the outcome of traumatic brain injury-associated gene expression and behavioral responses. FASEB journal, 37(11), e23218. Federation of American Societies for Experimental Biology 10.1096/fj.202301035R
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Psychological stress and traumatic brain injury (TBI) result in long-lasting emotional and behavioral impairments in patients. So far, the interaction of psychological stress with TBI not only in the brain but also in peripheral organs is poorly understood. Herein, the impact of acute stress (AS) occurring immediately before TBI is investigated. For this, a mouse model of restraint stress and TBI was employed, and their influence on behavior and gene expression in brain regions, the hypothalamic-pituitary-adrenal (HPA) axis, and peripheral organs was analyzed. Results demonstrate that, compared to single AS or TBI exposure, mice treated with AS prior to TBI showed sex-specific alterations in body weight, memory function, and locomotion. The induction of immediate early genes (IEGs, e.g., c-Fos) by TBI was modulated by previous AS in several brain regions. Furthermore, IEG upregulation along the HPA axis (e.g., pituitary, adrenal glands) and other peripheral organs (e.g., heart) was modulated by AS-TBI interaction. Proteomics of plasma samples revealed proteins potentially mediating this interaction. Finally, the deletion of Atf3 diminished the TBI-induced induction of IEGs in peripheral organs but left them largely unaltered in the brain. In summary, AS immediately before brain injury affects the brain and, to a strong degree, also responses in peripheral organs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Meier, Philip |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1530-6860 |
Publisher: |
Federation of American Societies for Experimental Biology |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
02 Oct 2023 16:15 |
Last Modified: |
03 Oct 2023 08:26 |
Publisher DOI: |
10.1096/fj.202301035R |
PubMed ID: |
37779443 |
Uncontrolled Keywords: |
ATF3 HPA axis acute stress immediate early gene traumatic brain injury |
BORIS DOI: |
10.48350/186860 |
URI: |
https://boris.unibe.ch/id/eprint/186860 |
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