Yilmaz, Kaan; Haeberle, Stefanie; Kim, Yong Ook; Fritzler, Marvin J.; Weng, Shih-Yen; Goeppert, Benjamin; Raker, Verena K.; Steinbrink, Kerstin; Schuppan, Detlef; Enk, Alexander; Hadaschik, Eva N. (2023). Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice. Frontiers in immunology, 14 Frontiers Research Foundation 10.3389/fimmu.2023.1253649
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Scurfy mice have a complete deficiency of functional regulatory T cells (Treg) due to a frameshift mutation in the Foxp3 gene. The impaired immune homeostasis results in a lethal lymphoproliferative disorder affecting multiple organs, including the liver. The autoimmune pathology in scurfy mice is in part accompanied by autoantibodies such as antinuclear antibodies (ANA). ANA are serological hallmarks of several autoimmune disorders including autoimmune liver diseases (AILD). However, the underlying pathogenesis and the role of Treg in AILD remain to be elucidated. The present study therefore aimed to characterize the liver disease in scurfy mice.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Goeppert, Frank Benjamin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Sandra Wittwer |
Date Deposited: |
10 Oct 2023 07:04 |
Last Modified: |
10 Oct 2023 07:04 |
Publisher DOI: |
10.3389/fimmu.2023.1253649 |
BORIS DOI: |
10.48350/186982 |
URI: |
https://boris.unibe.ch/id/eprint/186982 |
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