Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytes

von Gunten, Stephan; Simon, Hans-Uwe (2006). Sialic acid binding immunoglobulin-like lectins may regulate innate immune responses by modulating the life span of granulocytes. FASEB journal, 20(6), pp. 601-5. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.05-5401hyp

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The regulation of cell death is a key element in building up and maintaining both innate and adaptive immunity. A critical role in this process plays the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor family of death receptors. Recent work suggests that sialic acid binding immunoglobulin (Ig) -like lectins (Siglecs) are also empowered to transmit death signals, at least into myeloid cells. Strikingly, death induction by Siglecs is enhanced when cells are exposed to proinflammatory survival cytokines. Based on these recent insights, we hypothesize that at least some members of the Siglec family regulate immune responses via the activation of caspase-dependent and caspase-independent cell death pathways.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

ISSN:

0892-6638

ISBN:

16581967

Publisher:

Federation of American Societies for Experimental Biology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1096/fj.05-5401hyp

PubMed ID:

16581967

Web of Science ID:

000240130900005

URI:

https://boris.unibe.ch/id/eprint/18765 (FactScience: 1003)

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