Baur, Roland; Minier, Frédéric; Sigel, Erwin (2006). A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits. FEBS letters, 580(6), pp. 1616-20. Amsterdam: Elsevier 10.1016/j.febslet.2006.02.002
Full text not available from this repository.We show that the five subunits of a gamma-aminobutyric acid type A receptor (GABA(A) receptor) can be concatenated to yield a functional receptor. This concatenated receptor alpha(1)-beta(2)-alpha(1)-gamma(2)-beta(2) has the advantage of a known subunit arrangement. Most of its functional properties are not significantly different from a receptor formed by individual subunits. Extent of expression amounted to about 40% of that of non-concatenated receptors in Xenopus oocytes, after injection of oocytes with comparable amounts of cRNA coding for concatenated and non-concatenated receptors. The ability to express receptors consisting of five subunits enables detailed studies of GABA(A) receptor subtype selective compounds.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Minier, Frédéric, Sigel, Erwin |
ISSN: |
0014-5793 |
ISBN: |
16494876 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:45 |
Last Modified: |
05 Dec 2022 14:14 |
Publisher DOI: |
10.1016/j.febslet.2006.02.002 |
PubMed ID: |
16494876 |
Web of Science ID: |
000236058200015 |
URI: |
https://boris.unibe.ch/id/eprint/18770 (FactScience: 1008) |
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