A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits

Baur, Roland; Minier, Frédéric; Sigel, Erwin (2006). A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits. FEBS letters, 580(6), pp. 1616-20. Amsterdam: Elsevier 10.1016/j.febslet.2006.02.002

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We show that the five subunits of a gamma-aminobutyric acid type A receptor (GABA(A) receptor) can be concatenated to yield a functional receptor. This concatenated receptor alpha(1)-beta(2)-alpha(1)-gamma(2)-beta(2) has the advantage of a known subunit arrangement. Most of its functional properties are not significantly different from a receptor formed by individual subunits. Extent of expression amounted to about 40% of that of non-concatenated receptors in Xenopus oocytes, after injection of oocytes with comparable amounts of cRNA coding for concatenated and non-concatenated receptors. The ability to express receptors consisting of five subunits enables detailed studies of GABA(A) receptor subtype selective compounds.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Minier, Frédéric and Sigel, Erwin

ISSN:

0014-5793

ISBN:

16494876

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:45

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1016/j.febslet.2006.02.002

PubMed ID:

16494876

Web of Science ID:

000236058200015

URI:

https://boris.unibe.ch/id/eprint/18770 (FactScience: 1008)

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