Chiocchia, Virginia; Furukawa, Toshi A; Schneider-Thoma, Johannes; Siafis, Spyridon; Cipriani, Andrea; Leucht, Stefan; Salanti, Georgia (2023). Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis. Systematic Reviews, 12(1), p. 209. BioMed Central 10.1186/s13643-023-02376-1
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BACKGROUND
The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking metrics calculated from a single outcome. Some approaches have been proposed in the literature to account for multiple outcomes and individual preferences, such as the coverage area inside a spie chart, that, however, does not account for a trade-off between efficacy and safety outcomes. We present the net-benefit standardised area within a spie chart, [Formula: see text] to explore the changes in treatment performance with different trade-offs between benefits and harms, according to a particular set of preferences.
METHODS
We combine the standardised areas within spie charts for efficacy and safety/acceptability outcomes with a value λ specifying the trade-off between benefits and harms. We derive absolute probabilities and convert outcomes on a scale between 0 and 1 for inclusion in the spie chart.
RESULTS
We illustrate how the treatments in three published network meta-analyses perform as the trade-off λ varies. The decrease of the [Formula: see text] quantity appears more pronounced for some drugs, e.g. haloperidol. Changes in treatment performance seem more frequent when SUCRA is employed as outcome measures in the spie charts.
CONCLUSIONS
[Formula: see text] should not be interpreted as a ranking metric but it is a simple approach that could help identify which treatment is preferable when multiple outcomes are of interest and trading-off between benefits and harms is important.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Chiocchia, Virginia, Salanti, Georgia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2046-4053 |
Publisher: |
BioMed Central |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Nov 2023 14:21 |
Last Modified: |
26 Nov 2023 02:26 |
Publisher DOI: |
10.1186/s13643-023-02376-1 |
PubMed ID: |
37951949 |
Uncontrolled Keywords: |
Benefits Harms Multiple outcomes Network meta-analysis Spie charts Trade-off Treatment performance |
BORIS DOI: |
10.48350/188810 |
URI: |
https://boris.unibe.ch/id/eprint/188810 |
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