The role of IL-4 and IL-10 in degenerating intervertebral disc

Bermudez-Lekerika, Paola; Tseranidou, Sofia; Kanelis, Exarchos; Crump, Katherine B.; Le Maitre, Christine; Wuertz-Kosak, Karin; Alexopoulus, Leonidas G.; Noailly, Jérôme; Gantenbein, Benjamin (2023). The role of IL-4 and IL-10 in degenerating intervertebral disc. In: Annual Meeting of the Swiss Society of Biomedical Engineering. Allschwil, Switzerland. 13 September.

[img] Text
Bermudez_SSBE.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (605kB)


Intervertebral disc (IVD) degeneration is a pathological process often associated with chronic back pain and considered a leading cause of disability worldwide [1]. During degeneration, progressive structural changes occur leading to blood vessel and nerve ingrowth that promote discogenic pain [2]. In the last decades, several cytokines have been applied to IVD cells in vitro to investigate the degenerative cascade. Particularly, IL-10 and IL-4 have been predicted as important anabolic factors in the IVD according to a regulatory network model based in-silico approach [3]. Thus, we aim to investigate the potential presence and anabolic effect of IL-10 and IL-4 in human NP cells (in-vitro) and explants (ex-vivo) under hypoxia (5% O2 ).

Item Type:

Conference or Workshop Item (Abstract)


04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery

UniBE Contributor:

Bermudez, Paola, Crump, Katherine Briana, Gantenbein, Benjamin


600 Technology > 610 Medicine & health




Benjamin Gantenbein

Date Deposited:

16 Nov 2023 13:53

Last Modified:

16 Nov 2023 15:14




Actions (login required)

Edit item Edit item
Provide Feedback