Bermudez-Lekerika, Paola; Tseranidou, Sofia; Kanelis, Exarchos; Crump, Katherine B.; Le Maitre, Christine; Wuertz-Kosak, Karin; Alexopoulus, Leonidas G.; Noailly, Jérôme; Gantenbein, Benjamin (2023). The role of IL-4 and IL-10 in degenerating intervertebral disc. In: Annual Meeting of the Swiss Society of Biomedical Engineering. Allschwil, Switzerland. 13 September.
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Introduction
Intervertebral disc (IVD) degeneration is a pathological process often associated with chronic back pain and considered a leading cause of disability worldwide [1]. During degeneration, progressive structural changes occur leading to blood vessel and nerve ingrowth that promote discogenic pain [2]. In the last decades, several cytokines have been applied to IVD cells in vitro to investigate the degenerative cascade. Particularly, IL-10 and IL-4 have been predicted as important anabolic factors in the IVD according to a regulatory network model based in-silico approach [3]. Thus, we aim to investigate the potential presence and anabolic effect of IL-10 and IL-4 in human NP cells (in-vitro) and explants (ex-vivo) under hypoxia (5% O2 ).
Item Type: |
Conference or Workshop Item (Abstract) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery |
UniBE Contributor: |
Bermudez, Paola, Crump, Katherine Briana, Gantenbein, Benjamin |
Subjects: |
600 Technology > 610 Medicine & health |
Language: |
English |
Submitter: |
Benjamin Gantenbein |
Date Deposited: |
16 Nov 2023 13:53 |
Last Modified: |
16 Nov 2023 15:14 |
BORIS DOI: |
10.48350/188989 |
URI: |
https://boris.unibe.ch/id/eprint/188989 |
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