Long-term pulmonary outcome of children with congenital diaphragmatic hernia: functional lung MRI using matrix-pencil decomposition enables side-specific assessment of lung function.

Streibel, Carmen; Willers, C Corin; Bauman, Grzegorz; Pusterla, Orso; Bieri, Oliver; Curdy, Marion; Horn, Matthias; Casaulta, Carmen; Berger, Steffen; Dekany, Gabriela Marta; Kieninger, Elisabeth; Bartenstein, Andreas; Latzin, Philipp (2024). Long-term pulmonary outcome of children with congenital diaphragmatic hernia: functional lung MRI using matrix-pencil decomposition enables side-specific assessment of lung function. European radiology, 34(6), pp. 3773-3785. Springer-Verlag 10.1007/s00330-023-10395-8

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OBJECTIVES

In patients with congenital diaphragmatic hernia (CDH) the exact functional outcome of the affected lung side is still unknown, mainly due to the lack of spatially resolved diagnostic tools. Functional matrix-pencil decomposition (MP-) lung MRI fills this gap as it measures side-specific ventilation and perfusion. We aimed to assess the overall and side-specific pulmonary long-term outcomes of patients with CDH using lung function tests and MP-MRI.

METHODS

Thirteen school-aged children with CDH (seven with small and six with large defect-sized CDH, defined as > 50% of the chest wall circumference being devoid of diaphragm tissue) and thirteen healthy matched controls underwent spirometry, multiple-breath washout, and MP-MRI. The main outcomes were forced expiratory volume in 1 second (FEV1), lung clearance index (LCI2.5), ventilation defect percentage (VDP), and perfusion defect percentage (QDP).

RESULTS

Patients with a large CDH showed significantly reduced overall lung function compared to healthy controls (mean difference [95%-CIadjusted]: FEV1 (z-score) -4.26 [-5.61, -2.92], FVC (z-score) -3.97 [-5.68, -2.26], LCI2.5 (TO) 1.12 [0.47, 1.76], VDP (%) 8.59 [3.58, 13.60], QDP (%) 17.22 [13.16, 21.27]) and to patients with a small CDH. Side-specific examination by MP-MRI revealed particularly reduced ipsilateral ventilation and perfusion in patients with a large CDH (mean difference to contralateral side [95%-CIadjusted]: VDP (%) 14.80 [10.50, 19.00], QDP (%) 23.50 [1.75, 45.20]).

CONCLUSIONS

Data indicate impaired overall lung function with particular limitation of the ipsilateral side in patients with a large CDH. MP-MRI is a promising tool to provide valuable side-specific functional information in the follow-up of patients with CDH.

CLINICAL RELEVANCE STATEMENT

In patients with congenital diaphragmatic hernia, easily applicable MP-MRI allows specific examination of the lung side affected by the hernia and provides valuable information on ventilation and perfusion with implications for clinical practice, making it a promising tool for routine follow-up.

KEY POINTS

• Functional matrix pencil decomposition (MP) MRI data from a small sample indicate reduced ipsilateral pulmonary ventilation and perfusion in children with large congenital diaphragmatic hernia (CDH). • Easily applicable pencil decomposition MRI provides valuable side-specific diagnostic information on lung ventilation and perfusion. This is a clear advantage over conventional lung function tests, helping to comprehensively follow up patients with congenital diaphragmatic hernia and monitor therapy effects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Streibel, Carmen, Willers, Christoph Corin, Pusterla, Andrea Orso, Horn, Matthias Thomas, Casaulta, Carmen, Berger, Steffen Michael, Dekany, Gabriela Marta, Kieninger, Elisabeth, Bartenstein, Andreas, Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0938-7994

Publisher:

Springer-Verlag

Language:

English

Submitter:

Pubmed Import

Date Deposited:

21 Nov 2023 10:02

Last Modified:

12 Jun 2024 00:12

Publisher DOI:

10.1007/s00330-023-10395-8

PubMed ID:

37982833

Uncontrolled Keywords:

Children Congenital diaphragmatic hernias Functional magnetic resonance imaging Lung Pulmonary function test

BORIS DOI:

10.48350/189215

URI:

https://boris.unibe.ch/id/eprint/189215

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