Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia

Draeger, A; Monastyrskaya, K; Mohaupt, M; Hoppeler, H; Savolainen, H; Allemann, C; Babiychuk, E B (2006). Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia. Journal of pathology, 210(1), pp. 94-102. Chichester: Wiley 10.1002/path.2018

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Muscle pain and weakness are frequent complaints in patients receiving 3-hydroxymethylglutaryl coenzymeA (HMG CoA) reductase inhibitors (statins). Many patients with myalgia have creatine kinase levels that are either normal or only marginally elevated, and no obvious structural defects have been reported in patients with myalgia only. To investigate further the mechanism that mediates statin-induced skeletal muscle damage, skeletal muscle biopsies from statin-treated and non-statin-treated patients were examined using both electron microscopy and biochemical approaches. The present paper reports clear evidence of skeletal muscle damage in statin-treated patients, despite their being asymptomatic. Though the degree of overall damage is slight, it has a characteristic pattern that includes breakdown of the T-tubular system and subsarcolemmal rupture. These characteristic structural abnormalities observed in the statin-treated patients were reproduced by extraction of cholesterol from skeletal muscle fibres in vitro. These findings support the hypothesis that statin-induced cholesterol lowering per se contributes to myocyte damage and suggest further that it is the specific lipid/protein organization of the skeletal muscle cell itself that renders it particularly vulnerable.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Draeger, Annette; Monastyrskaya-Stäuber, Katia; Mohaupt, Markus; Hoppeler, Hans-Heinrich; Savolainen, Hannu Olavi and Babiychuk, Eduard

ISSN:

0022-3417

ISBN:

16799920

Publisher:

Wiley

Language:

English

Submitter:

Markus Georg Mohaupt

Date Deposited:

04 Oct 2013 14:46

Last Modified:

26 Feb 2014 04:37

Publisher DOI:

10.1002/path.2018

PubMed ID:

16799920

Web of Science ID:

000240040800013

URI:

https://boris.unibe.ch/id/eprint/18922 (FactScience: 1193)

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