Regenerative capacity of individual liver lobes in the microsurgical mouse model

Inderbitzin, Daniel; Studer, Peter; Sidler, Daniel; Beldi, Guido; Djonov, Valentin; Keogh, Adrian; Candinas, Daniel (2006). Regenerative capacity of individual liver lobes in the microsurgical mouse model. Microsurgery, 26(6), pp. 465-9. New York, N.Y.: Wiley-Liss 10.1002/micr.20271

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In the development of microsurgical mouse models of hepatic regeneration and repair, lobe-specific regenerative responses were observed. We therefore determined the hepatic regenerative capacity of individual mouse liver lobes. In mice, 26, 60, 75, and 83% of total liver mass was resected. Bromo-deoxyuridine (BrdU) was injected prior to liver harvest and the BrdU labeling index determined in all remaining individual liver lobes. BrdU-positive nuclei were seen in all liver lobes after the 26 and 60% resection, but significantly fewer were detected in the caudate lobe. In the 75% group, equally distributed positive nuclei were found. However, BrdU labeling was scant in the 83% group. In microsurgical mouse liver-regeneration models, the average hepatic response depends on amount of liver tissue resected and on the remaining liver lobe. BrdU incorporation can vary significantly among individual lobes. The lobe-specific differences observed may prove valuable in further investigations of hepatic regeneration and repair.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Inderbitzin, Daniel; Studer, Peter; Beldi, Guido; Djonov, Valentin; Keogh, Adrian and Candinas, Daniel

ISSN:

0738-1085

ISBN:

16924633

Publisher:

Wiley-Liss

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

04 May 2014 23:13

Publisher DOI:

10.1002/micr.20271

PubMed ID:

16924633

Web of Science ID:

000240694000008

URI:

https://boris.unibe.ch/id/eprint/18936 (FactScience: 1207)

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