Regenerative capacity of individual liver lobes in the microsurgical mouse model

Inderbitzin, Daniel; Studer, Peter; Sidler, Daniel; Beldi, Guido; Djonov, Valentin; Keogh, Adrian; Candinas, Daniel (2006). Regenerative capacity of individual liver lobes in the microsurgical mouse model. Microsurgery, 26(6), pp. 465-9. New York, N.Y.: Wiley-Liss 10.1002/micr.20271

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In the development of microsurgical mouse models of hepatic regeneration and repair, lobe-specific regenerative responses were observed. We therefore determined the hepatic regenerative capacity of individual mouse liver lobes. In mice, 26, 60, 75, and 83% of total liver mass was resected. Bromo-deoxyuridine (BrdU) was injected prior to liver harvest and the BrdU labeling index determined in all remaining individual liver lobes. BrdU-positive nuclei were seen in all liver lobes after the 26 and 60% resection, but significantly fewer were detected in the caudate lobe. In the 75% group, equally distributed positive nuclei were found. However, BrdU labeling was scant in the 83% group. In microsurgical mouse liver-regeneration models, the average hepatic response depends on amount of liver tissue resected and on the remaining liver lobe. BrdU incorporation can vary significantly among individual lobes. The lobe-specific differences observed may prove valuable in further investigations of hepatic regeneration and repair.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
UniBE Contributor:	Inderbitzin, Daniel, Studer, Peter, Beldi, Guido Jakob Friedrich, Djonov, Valentin Georgiev, Keogh, Adrian, Candinas, Daniel
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0738-1085
ISBN:	16924633
Publisher:	Wiley-Liss
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:46
Last Modified:	05 Dec 2022 14:14
Publisher DOI:	10.1002/micr.20271
PubMed ID:	16924633
Web of Science ID:	000240694000008
URI:	https://boris.unibe.ch/id/eprint/18936 (FactScience: 1207)