Association between Total Dietary Phytochemical Intake and Cardiometabolic Health Outcomes-Results from a 10-Year Follow-Up on a Middle-Aged Cohort Population.

Gamba, Magda; Pano, Octavio; Raguindin, Peter Francis; Roa-Diaz, Zayne M; Muka, Taulant; Glisic, Marija; Franco, Oscar H; Marques-Vidal, Pedro (2023). Association between Total Dietary Phytochemical Intake and Cardiometabolic Health Outcomes-Results from a 10-Year Follow-Up on a Middle-Aged Cohort Population. Nutrients, 15(22), p. 4793. Molecular Diversity Preservation International MDPI 10.3390/nu15224793

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Dietary phytochemical intake associations with cardiovascular health and mortality remain unknown. We studied the relations between total dietary phytochemical intake and cardiovascular health outcomes in a middle-aged Swiss population. We analyzed data spanning 2009 to 2021 from a prospective cohort study in Lausanne, Switzerland, including 3721 participants (54.8% women, 57.2 ± 10.3 years) without cardiovascular disease (CVD) history. Dietary intake was assessed using a validated self-reported food frequency questionnaire. The Dietary Phytochemical Index (DPI) and the healthy Dietary Phytochemical Index (hDPI) were calculated as the total energy intake percentage obtained from phytochemical-rich food consumption. The Healthy Plant-Based Diet Index (hPBD) was estimated by scoring healthy plant foods positively and less-healthy plant foods negatively. Indices tertiles and cardiometabolic outcome associations were determined using Cox proportional hazard models. Over 30,217 person-years of follow-up, 262 CVD events, and 178 deaths occurred. Unadjusted analyses found 36%, 33%, and 32% lower CVD risk for the highest hDPI, DPI, and hPBD tertiles, respectively. After adjustment, only the second hDPI tertile showed a 30% lower CVD risk (HR 0.70, 95% CI 0.51-0.95; P for trend 0.362). No other associations emerged. In this middle-aged Swiss cohort, no associations between dietary indices reflecting a phytochemical-rich dietary pattern and incident CVD, all-cause, or CVD mortality were observed.

Item Type:

Journal Article (Original Article)


13 Central Units > Administrative Director's Office > University Library of Bern
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Gamba Rincón, Magda Rocío, Pano Espinola, Octavio, Roa Diaz, Zayne Milena, Muka, Taulant, Glisic, Marija, Franco Duran, Oscar Horacio


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
000 Computer science, knowledge & systems > 020 Library & information sciences




Molecular Diversity Preservation International MDPI


[4] Swiss National Science Foundation




Pubmed Import

Date Deposited:

28 Nov 2023 15:43

Last Modified:

30 Nov 2023 18:11

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Dietary Phytochemical Index Healthy Plant-Based Diet Index all-cause mortality cardiovascular disease incidence phytochemical-rich foods prospective study




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