ABO histo-blood group antigen expression on the graft endothelium long term after ABO-compatible, non-identical heart transplantation

Koestner, Simon C; Kappeler, Andreas; Schaffner, Thomas; Carrel, Thierry P; Mohacsi, Paul J (2006). ABO histo-blood group antigen expression on the graft endothelium long term after ABO-compatible, non-identical heart transplantation. Xenotransplantation, 13(2), pp. 166-70. Hoboken, N.J.: Wiley 10.1111/j.1399-3089.2006.00288.x

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We recently reported a complete change in the endothelial ABO histo-blood group phenotype of a cardiac allograft long term after B to O mismatched transplantation. In the context of the current controversy on graft recolonization with recipient endothelial cells and its importance in the development of immunological unresponsiveness, we monitored the expression of endothelial ABH histo-blood group antigens of 10 ABO-compatible, non-identical cardiac allografts over an observation period of at least 30 months. ABH antigens as well as markers for endothelial cells, erythrocytes and thrombocytes were investigated retrospectively by immunohistochemistry using monoclonal antibodies on sections of formalin-fixed, paraffin-embedded biopsies and were evaluated semi-quantitatively by microscopy. In contrast to our earlier finding of the change in the endothelial ABO histo-blood group phenotype long term after ABO- mismatched transplantation, we could not confirm this change in 10 compatible but non-identical cases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Kappeler, Andreas; Schaffner, Thomas; Carrel, Thierry and Mohacsi, Paul

ISSN:

0908-665X

ISBN:

16623813

Publisher:

Wiley

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

06 Dec 2013 13:41

Publisher DOI:

10.1111/j.1399-3089.2006.00288.x

PubMed ID:

16623813

Web of Science ID:

000236219500016

URI:

https://boris.unibe.ch/id/eprint/19046 (FactScience: 1414)

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