Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans

de Marchi, Stefano F.; Meier, Pascal; Oswald, Philipp; Seiler, Christian (2006). Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans. American journal of physiology - heart and circulatory physiology, 291(1), H351-H356. Bethesda, Md.: American Physiological Society 10.1152/ajpheart.00992.2005

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Infarct size (IS) increases with vascular occlusion time, area at risk for infarction, lack of collateral supply, absence of preconditioning, and myocardial demand for O2 supply. ECG S-T segment elevation is used as a measure of severity of ischemia and a surrogate for IS. This study in 50 patients with coronary artery disease undergoing a first 120-s balloon occlusion of a stenosis sought to determine whether S-T segment elevation, corrected for the above-mentioned variables, in the left coronary artery (LCA group, n = 36) is different from that in the right coronary artery (RCA group, n = 14) territory. After consideration of all known determinants of IS, particularly mass at risk and collateral supply, the LCA territory is more sensitive than the RCA region to a 2-min period of myocardial ischemia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

de Marchi, Stefano and Seiler, Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0363-6135

ISBN:

16428337

Publisher:

American Physiological Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

09 Jul 2014 14:03

Publisher DOI:

10.1152/ajpheart.00992.2005

PubMed ID:

16428337

Web of Science ID:

000238262500044

URI:

https://boris.unibe.ch/id/eprint/19053 (FactScience: 1421)

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