Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans

de Marchi, Stefano F.; Meier, Pascal; Oswald, Philipp; Seiler, Christian (2006). Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans. American journal of physiology - heart and circulatory physiology, 291(1), H351-H356. Bethesda, Md.: American Physiological Society 10.1152/ajpheart.00992.2005

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Infarct size (IS) increases with vascular occlusion time, area at risk for infarction, lack of collateral supply, absence of preconditioning, and myocardial demand for O2 supply. ECG S-T segment elevation is used as a measure of severity of ischemia and a surrogate for IS. This study in 50 patients with coronary artery disease undergoing a first 120-s balloon occlusion of a stenosis sought to determine whether S-T segment elevation, corrected for the above-mentioned variables, in the left coronary artery (LCA group, n = 36) is different from that in the right coronary artery (RCA group, n = 14) territory. After consideration of all known determinants of IS, particularly mass at risk and collateral supply, the LCA territory is more sensitive than the RCA region to a 2-min period of myocardial ischemia.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	De Marchi, Stefano, Seiler, Christian
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0363-6135
ISBN:	16428337
Publisher:	American Physiological Society
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:46
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.1152/ajpheart.00992.2005
PubMed ID:	16428337
Web of Science ID:	000238262500044
URI:	https://boris.unibe.ch/id/eprint/19053 (FactScience: 1421)