Increased erythroferrone levels in malarial anaemia.

Neyer, Peter J; Kaboré, Bérenger; Nakas, Christos T; Diallo, Salou; Tinto, Halidou; Post, Annelies; van der Ven, Andre J; Huber, Andreas R; Largiadèr, Carlo R; Hammerer-Lercher, Angelika (2024). Increased erythroferrone levels in malarial anaemia. British journal of haematology, 204(5), pp. 2066-2070. Wiley 10.1111/bjh.19309

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We assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.

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