Increased erythroferrone levels in malarial anaemia.

Neyer, Peter J; Kaboré, Bérenger; Nakas, Christos T; Diallo, Salou; Tinto, Halidou; Post, Annelies; van der Ven, Andre J; Huber, Andreas R; Largiadèr, Carlo R; Hammerer-Lercher, Angelika (2024). Increased erythroferrone levels in malarial anaemia. British journal of haematology, 204(5), pp. 2066-2070. Wiley 10.1111/bjh.19309

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We assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

Graduate School:

Graduate School Gender Studies

UniBE Contributor:

Nakas, Christos T., Largiadèr, Carlo Rodolfo

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1365-2141

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

29 Jan 2024 10:19

Last Modified:

15 May 2024 00:13

Publisher DOI:

10.1111/bjh.19309

PubMed ID:

38279554

Uncontrolled Keywords:

anaemia iron biochemistry malaria

BORIS DOI:

10.48350/192188

URI:

https://boris.unibe.ch/id/eprint/192188

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