Knäusl, Barbara; Belotti, Gabriele; Bertholet, Jenny; Daartz, Juliane; Flampouri, Stella; Hoogeman, Mischa; Knopf, Antje C; Lin, Haibo; Moerman, Astrid; Paganelli, Chiara; Rucinski, Antoni; Schulte, Reinhard; Shimizu, Shing; Stützer, Kristin; Zhang, Xiaodong; Zhang, Ye; Czerska, Katarzyna (2024). A review of the clinical introduction of 4D particle therapy research concepts. Physics and imaging in radiation oncology, 29(100535) Elsevier 10.1016/j.phro.2024.100535
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BACKGROUND AND PURPOSE
Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and outline a roadmap for future research and developments.
MATERIAL AND METHODS
This review focused on the clinical implementation of 4D approaches for imaging, treatment planning, delivery and evaluation based on the 2021 and 2022 4D Treatment Workshops for Particle Therapy as well as a review of the most recent surveys, guidelines and scientific papers dedicated to this topic.
RESULTS
Available technological capabilities for motion surveillance and compensation determined the course of each 4D particle treatment. 4D motion management, delivery techniques and strategies including imaging were diverse and depended on many factors. These included aspects of motion amplitude, tumour location, as well as accelerator technology driving the necessity of centre-specific dosimetric validation. Novel methodologies for X-ray based image processing and MRI for real-time tumour tracking and motion management were shown to have a large potential for online and offline adaptation schemes compensating for potential anatomical changes over the treatment course. The latest research developments were dominated by particle imaging, artificial intelligence methods and FLASH adding another level of complexity but also opportunities in the context of 4D treatments.
CONCLUSION
This review showed that the rapid technological advances in radiation oncology together with the available intrafractional motion management and adaptive strategies paved the way towards clinical implementation.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Bertholet, Jenny |
Subjects: |
500 Science > 530 Physics 600 Technology > 610 Medicine & health |
ISSN: |
2405-6316 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 Feb 2024 15:39 |
Last Modified: |
01 Feb 2024 15:50 |
Publisher DOI: |
10.1016/j.phro.2024.100535 |
PubMed ID: |
38298885 |
Uncontrolled Keywords: |
4D Treatment Workshop for Particle Therapy 4D dose reconstruction 4D imaging Adaptive workflows Intrafractional motion Motion management Particle therapy |
BORIS DOI: |
10.48350/192345 |
URI: |
https://boris.unibe.ch/id/eprint/192345 |
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