Rauch, A; Nolan, D; Martin, A; McKinnon, E; Almeida, C; Mallal, Simon (2006). Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clinical infectious diseases, 43(1), pp. 99-102. Cary, N.C.: The University of Chicago Press 10.1086/504874
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Abacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allele. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
ISSN: |
1058-4838 |
ISBN: |
16758424 |
Publisher: |
The University of Chicago Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:46 |
Last Modified: |
05 Dec 2022 14:14 |
Publisher DOI: |
10.1086/504874 |
PubMed ID: |
16758424 |
Web of Science ID: |
000238030000015 |
BORIS DOI: |
10.7892/boris.19240 |
URI: |
https://boris.unibe.ch/id/eprint/19240 (FactScience: 1727) |
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