Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Rauch, A; Nolan, D; Martin, A; McKinnon, E; Almeida, C; Mallal, Simon (2006). Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clinical infectious diseases, 43(1), pp. 99-102. Cary, N.C.: The University of Chicago Press 10.1086/504874

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Abacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allele. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Rauch, Andri

ISSN:

1058-4838

ISBN:

16758424

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:46

Last Modified:

27 Apr 2018 10:12

Publisher DOI:

10.1086/504874

PubMed ID:

16758424

Web of Science ID:

000238030000015

BORIS DOI:

10.7892/boris.19240

URI:

https://boris.unibe.ch/id/eprint/19240 (FactScience: 1727)

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