Getting the phase consistent: The importance of phase description in balanced steady-state free precession MRI of multi-compartment systems.

Plähn, Nils M J; Poli, Simone; Peper, Eva S.; Açıkgöz, Berk C.; Kreis, Roland; Ganter, Carl; Bastiaansen, Jessica A. M. (2024). Getting the phase consistent: The importance of phase description in balanced steady-state free precession MRI of multi-compartment systems. Magnetic resonance in medicine, 92(1), pp. 215-225. Wiley-Liss 10.1002/mrm.30033

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PURPOSE

Determine the correct mathematical phase description for balanced steady-state free precession (bSSFP) signals in multi-compartment systems.

THEORY AND METHODS

Based on published bSSFP signal models, different phase descriptions can be formulated: one predicting the presence and the other predicting the absence of destructive interference effects in multi-compartment systems. Numerical simulations of bSSFP signals of water and acetone were performed to evaluate the predictions of these different phase descriptions. For experimental validation, bSSFP profiles were measured at 3T using phase-cycled bSSFP acquisitions performed in a phantom containing mixtures of water and acetone, which replicates a system with two signal components. Localized single voxel MRS was performed at 7T to determine the relative chemical shift of the acetone-water mixtures.

RESULTS

Based on the choice of phase description, the simulated bSSFP profiles of water-acetone mixtures varied significantly, either displaying or lacking destructive interference effects, as predicted theoretically. In phantom experiments, destructive interference was consistently observed in the measured bSSFP profiles of water-acetone mixtures, supporting the theoretical description that predicts such interference effects. The connection between the choice of phase description and predicted observation enables unambiguous experimental identification of the correct phase description for multi-compartment bSSFP profiles, which is consistent with the Bloch equations.

CONCLUSION

The study emphasizes that consistent phase descriptions are crucial for accurately describing multi-compartment bSSFP signals, as incorrect phase descriptions result in erroneous predictions.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology > DCR Magnetic Resonance Spectroscopy and Methodology (AMSM)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Faculty Institutions > sitem Center for Translational Medicine and Biomedical Entrepreneurship

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Plähn, Nils Marc Joel, Poli, Simone, Peper, Eva Sophia, Açıkgöz, Berk Can, Kreis, Roland, Bastiaansen, Jessica

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0740-3194

Publisher:

Wiley-Liss

Language:

English

Submitter:

Pubmed Import

Date Deposited:

07 Feb 2024 10:40

Last Modified:

13 May 2024 10:09

Publisher DOI:

10.1002/mrm.30033

PubMed ID:

38321594

Uncontrolled Keywords:

asymmetries balanced steady-state free precession multi-compartment phase definition phase-cycled bSSFP signal model

BORIS DOI:

10.48350/192644

URI:

https://boris.unibe.ch/id/eprint/192644

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