Musonda, Taonga; Wallace, Michael S; Patel, Hailey; Martin, Owen P; Oetheimer, Christopher; Mwakamui, Simutanyi; Sinkala, Edford; Nsokolo, Bright; Kanunga, Annie; Lauer, Georg; Chung, Raymond T; Wandeler, Gilles; Bhattacharya, Debika; Kelly, Paul; Alatrakchi, Nadia; Vinikoor, Michael J (2024). New window into hepatitis B in Africa: Liver sampling combined with single cell omics enables deep and longitudinal assessment of intrahepatic immunity in Zambia. (In Press). Journal of infectious diseases Oxford University Press 10.1093/infdis/jiae054
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In Lusaka, Zambia, we introduced liver fine needle aspiration (FNA) into a research cohort of adults with treatment-naïve chronic hepatitis B virus (HBV) infection, with and without HIV coinfection, as well as with acute HBV infection. Over 117 enrollment and 47 longitudinal FNAs (at 1 year follow-up), we established participant acceptability and safety. We also demonstrated the quality of the material through single cell RNA sequencing of selected enrollment FNAs, which revealed a range of immune cells. This approach can drive new insights into HBV immunology, informing cure strategies, and can improve our understanding of HBV natural history in Africa.
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