Kleban, Elena; Jones, Derek K; Tax, Chantal M W (2023). The impact of head orientation with respect to B0 on diffusion tensor MRI measures. Imaging neuroscience, 1, pp. 1-17. MIT Press Direct 10.1162/imag_a_00012
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Diffusion tensor MRI (DT-MRI) remains the most commonly used approach to characterise white matter (WM) anisotropy. However, DT estimates may be affected by tissue orientation w.r.t. due to local gradients and intrinsic orientation dependence induced by the microstructure. This work aimed to investigate whether and how diffusion tensor MRI-derived measures depend on the orientation of the head with respect to the static magnetic field, . By simulating WM as two compartments, we demonstrated that compartmental anisotropy can induce the dependence of diffusion tensor measures on the angle between WM fibres and the magnetic field. In in vivo experiments, reduced radial diffusivity and increased axial diffusivity were observed in white matter fibres perpendicular to compared to those parallel to . Fractional anisotropy varied by up to as a function of the angle between WM fibres and the orientation of the main magnetic field. To conclude, fibre orientation w.r.t. is responsible for up to variance in diffusion tensor measures across the whole brain white matter from all subjects and head orientations. Fibre orientation w.r.t. may introduce additional variance in clinical research studies using diffusion tensor imaging, particularly when it is difficult to control for (e.g., fetal or neonatal imaging, or when the trajectories of fibres change due to, e.g., space occupying lesions).
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Kleban, Elena |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2837-6056 |
Publisher: |
MIT Press Direct |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Feb 2024 15:57 |
Last Modified: |
27 Feb 2024 16:07 |
Publisher DOI: |
10.1162/imag_a_00012 |
PubMed ID: |
38405373 |
Uncontrolled Keywords: |
diffusion tensor imaging fibre direction magnetic resonance imaging orientation anisotropy transverse relaxation |
BORIS DOI: |
10.48350/193271 |
URI: |
https://boris.unibe.ch/id/eprint/193271 |
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