Burri, Christian; Salzmann, Simon; Wandel, Jasmin; Hoffmann, Leonie; Považay, Boris; Meier, Christoph; Frenz, Martin (2023). Real-time OCT feedback-controlled RPE photodisruption in ex vivo porcine eyes using 8 microsecond laser pulses. Biomedical optics express, 14(12), pp. 6328-6349. Optical Society of America 10.1364/BOE.503941
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Selective retinal pigment epithelium (RPE) photodisruption requires reliable real-time feedback dosimetry (RFD) to prevent unwanted overexposure. In this study, optical coherence tomography (OCT) based RFD was investigated in ex vivo porcine eyes exposed to laser pulses of 8 µs duration (wavelength: 532 nm, exposure area: 90 × 90 µm2, radiant exposure: 247 to 1975 mJ/µm2). For RFD, fringe washouts in time-resolved OCT M-scans (central wavelength: 870 nm, scan rate: 85 kHz) were compared to an RPE cell viability assay. Statistical analysis revealed a moderate correlation between RPE lesion size and applied treatment energy, suggesting RFD adaptation to inter- and intraindividual RPE pigmentation and ocular transmission.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics 08 Faculty of Science > Institute of Applied Physics |
UniBE Contributor: |
Frenz, Martin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology > 620 Engineering |
ISSN: |
2156-7085 |
Publisher: |
Optical Society of America |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 Mar 2024 07:23 |
Last Modified: |
01 Mar 2024 07:31 |
Publisher DOI: |
10.1364/BOE.503941 |
PubMed ID: |
38420306 |
BORIS DOI: |
10.48350/193638 |
URI: |
https://boris.unibe.ch/id/eprint/193638 |
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