Chen, Xin; Tsvetkov, Andrey S; Shen, Han-Ming; Isidoro, Ciro; Ktistakis, Nicholas T; Linkermann, Andreas; Koopman, Werner J H; Simon, Hans-Uwe; Galluzzi, Lorenzo; Luo, Shouqing; Xu, Daqian; Gu, Wei; Peulen, Olivier; Cai, Qian; Rubinsztein, David C; Chi, Jen-Tsan; Zhang, Donna D; Li, Changfeng; Toyokuni, Shinya; Liu, Jinbao; ... (2024). International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy, 20(6), pp. 1213-1246. Taylor & Francis 10.1080/15548627.2024.2319901
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International_consensus_guidelines_for_the_definition_detection_and_interpretation_of_autophagy-dependent_ferroptosis.pdf - Accepted Version Restricted to registered users only until 5 March 2025. Available under License Publisher holds Copyright. Download (2MB) |
Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Simon, Hans-Uwe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1554-8635 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 Mar 2024 09:23 |
Last Modified: |
22 Jun 2024 00:13 |
Publisher DOI: |
10.1080/15548627.2024.2319901 |
PubMed ID: |
38442890 |
Uncontrolled Keywords: |
Cell death ferritinophagy iron lipid peroxidation lipophagy lysosome |
BORIS DOI: |
10.48350/193887 |
URI: |
https://boris.unibe.ch/id/eprint/193887 |
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