Sanfeliu-Redondo, David; Gibert-Ramos, Albert; Gracia-Sancho, Jordi (2024). Cell senescence in liver diseases: pathological mechanism and theranostic opportunity. Nature reviews. Gastroenterology & hepatology, 21(7), pp. 477-492. Springer Nature 10.1038/s41575-024-00913-4
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The liver is not oblivious to the passage of time, as ageing is a major risk factor for the development of acute and chronic liver diseases. Ageing produces alterations in all hepatic cells, affecting their phenotype and function and worsening the prognosis of liver disease. The ageing process also implies the accumulation of a cellular state characterized by a persistent proliferation arrest and a specific secretory phenotype named cellular senescence. Indeed, senescent cells have key roles in many physiological processes; however, their accumulation owing to ageing or pathological conditions contributes to the damage occurring in chronic diseases. The aim of this Review is to provide an updated description of the pathophysiological events in which hepatic senescent cells are involved and their role in liver disease progression. Finally, we discuss novel geroscience therapies that could be applied to prevent or improve liver diseases and age-mediated hepatic deregulations.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Jordi, Gracia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1759-5053 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Mar 2024 12:37 |
Last Modified: |
30 Jun 2024 00:13 |
Publisher DOI: |
10.1038/s41575-024-00913-4 |
PubMed ID: |
38485755 |
BORIS DOI: |
10.48350/194330 |
URI: |
https://boris.unibe.ch/id/eprint/194330 |
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