Miron, Richard J; Estrin, Nathan E; Sculean, Anton; Zhang, Yufeng (2024). Understanding exosomes: Part 2-Emerging leaders in regenerative medicine. (In Press). Periodontology 2000 Blackwell 10.1111/prd.12561
|
Text
Periodontology_2000_-_2024_-_Miron_-_Understanding_exosomes_Part_2_Emerging_leaders_in_regenerative_medicine.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (37MB) | Preview |
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. Today exosomes have been applied in numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's disease, post-traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology disorders, musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID-19, hepatitis), regenerative procedures (antiaging, bone regeneration, cartilage/joint regeneration, osteoarthritis, cutaneous wounds, dental regeneration, dermatology/skin regeneration, erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord injury, vascular regeneration), and cancer therapy (breast, colorectal, gastric cancer and osteosarcomas), immune function (allergy, autoimmune disorders, immune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review is a first of its kind aimed at summarizing the extensive regenerative potential of exosomes over a broad range of diseases and disorders.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Miron, Richard John, Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0906-6713 |
Publisher: |
Blackwell |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Apr 2024 08:13 |
Last Modified: |
11 Apr 2024 02:42 |
Publisher DOI: |
10.1111/prd.12561 |
PubMed ID: |
38591622 |
Uncontrolled Keywords: |
dermasomes exosomes immunosomes regenerative medicine ultra‐centrifugation |
BORIS DOI: |
10.48350/195828 |
URI: |
https://boris.unibe.ch/id/eprint/195828 |
Actions (login required)
 |
Edit item |