Aberrant brain dynamics in individuals with clinical high risk of psychosis.

Kindler, Jochen; Ishida, Takuya; Michel, Chantal; Klaassen, Arndt-Lukas; Stüble, Miriam; Zimmermann, Nadja; Wiest, Roland; Kaess, Michael; Morishima, Yosuke (2024). Aberrant brain dynamics in individuals with clinical high risk of psychosis. Schizophrenia Bulletin Open, 5(1) Oxford University Press 10.1093/schizbullopen/sgae002

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Resting-state network (RSN) functional connectivity analyses have profoundly influenced our understanding of the pathophysiology of psychoses and their clinical high risk (CHR) states. However, conventional RSN analyses address the static nature of large-scale brain networks. In contrast, novel methodological approaches aim to assess the momentum state and temporal dynamics of brain network interactions.


Fifty CHR individuals and 33 healthy controls (HC) completed a resting-state functional MRI scan. We performed an Energy Landscape analysis, a data-driven method using the pairwise maximum entropy model, to describe large-scale brain network dynamics such as duration and frequency of, and transition between, different brain states. We compared those measures between CHR and HC, and examined the association between neuropsychological measures and neural dynamics in CHR.


Our main finding is a significantly increased duration, frequency, and higher transition rates to an infrequent brain state with coactivation of the salience, limbic, default mode and somatomotor RSNs in CHR as compared to HC. Transition of brain dynamics from this brain state was significantly correlated with processing speed in CHR.


In CHR, temporal brain dynamics are attracted to an infrequent brain state, reflecting more frequent and longer occurrence of aberrant interactions of default mode, salience, and limbic networks. Concurrently, more frequent and longer occurrence of the brain state is associated with core cognitive dysfunctions, predictors of future onset of full-blown psychosis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Kindler, Jochen, Michel, Chantal, Stüble, Miriam, Zimmermann, Nadja, Wiest, Roland Gerhard Rudi, Kaess, Michael, Morishima, Yosuke


600 Technology > 610 Medicine & health




Oxford University Press




Pubmed Import

Date Deposited:

12 Apr 2024 15:46

Last Modified:

12 Apr 2024 15:56

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Cognitive dysfunction Dynamic functional connectivity Energy landscape Psychosis network prodromal state





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