Case report: Chronic Candida albicans meningitis: a rare entity diagnosed by metagenomic next-generation sequencing.

Kuenzli, Andrea B; Müller, Mandy D; Z'Graggen, Werner J; Walti, Laura N; Martin, Yonas; Lazarevic, Vladimir; Schrenzel, Jacques; Oberli, Alexander (2024). Case report: Chronic Candida albicans meningitis: a rare entity diagnosed by metagenomic next-generation sequencing. Frontiers in cellular and infection microbiology, 14(1322847) Frontiers 10.3389/fcimb.2024.1322847

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The aetiology of chronic aseptic meningitis is difficult to establish. Candida meningitis in particular is often diagnosed late, as cerebrospinal fluid (CSF) work-up and imaging findings are nonspecific. A 35-year-old patient with chronic aseptic meningitis, for which repeated microbiological testing of CSF was unrevealing, was finally diagnosed with Candida albicans (C. albicans) meningitis with cauda equina involvement using metagenomic next-generation sequencing (mNGS). This report highlights the diagnostic challenges and the difficulties of treating shunt-associated fungal meningitis.

Item Type:

 Journal Article (Further Contribution)

Division/Institute:

 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

 Künzli, Andrea Brigitte, Müller, Mandy, Z'Graggen, Werner Josef, Walti, Laura Naëmi, Martin, Yonas Arrefaine, Oberli, Alexander Oliver

Subjects:

 500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

 2235-2988

Publisher:

 Frontiers

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 07 May 2024 14:19

Last Modified:

 07 May 2024 14:28

Publisher DOI:

 10.3389/fcimb.2024.1322847

PubMed ID:

 38707513

Uncontrolled Keywords:

 (1,3)-beta-D-glucan Candida albicans cerebrospinal fluid chronic meningitis metagenomic next-generation sequencing ventriculitis

BORIS DOI:

 10.48350/196562

URI:

 https://boris.unibe.ch/id/eprint/196562

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