Jandrasits, Damian; Züst, Roland; Siegrist, Denise; Engler, Olivier B; Weber, Benjamin; Schmidt, Kristina M; Jonsdottir, Hulda R (2024). Third-generation smallpox vaccines induce low-level cross-protecting neutralizing antibodies against Monkeypox virus in laboratory workers. Heliyon, 10(10) Elsevier 10.1016/j.heliyon.2024.e31490
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Due to the discontinuation of routine smallpox vaccination after its eradication in 1980, a large part of the human population remains naïve against smallpox and other members of the orthopoxvirus genus. As a part of biosafety personnel protection programs, laboratory workers receive prophylactic vaccinations against diverse infectious agents, including smallpox. Here, we studied the levels of cross-protecting neutralizing antibodies as well as total IgG induced by either first- or third-generation smallpox vaccines against Monkeypox virus, using a clinical isolate from the 2022 outbreak. Serum neutralization tests indicated better overall neutralization capacity after vaccination with first-generation smallpox vaccines, compared to an attenuated third-generation vaccine. Results obtained from total IgG ELISA, however, did not show higher induction of orthopoxvirus-specific IgGs in first-generation vaccine recipients. Taken together, our results indicate a lower level of cross-protecting neutralizing antibodies against Monkeypox virus in recipients of third-generation smallpox vaccine compared to first-generation vaccine recipients, although total IgG levels were comparable.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Jonsdottir, Hulda Run |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2405-8440 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Jun 2024 15:28 |
Last Modified: |
04 Jun 2024 03:12 |
Publisher DOI: |
10.1016/j.heliyon.2024.e31490 |
PubMed ID: |
38826712 |
Uncontrolled Keywords: |
ELISA Imvamune/Imvanex/Jynneos Monkeypox virus Neutralizing antibodies Occupational biosafety Vaccines Vaccinia virus serum neutralization test |
BORIS DOI: |
10.48350/197518 |
URI: |
https://boris.unibe.ch/id/eprint/197518 |
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