Adaptations of intestinal macrophages to an antigen-rich environment

Schenk, Mirjam; Mueller, Christoph (2007). Adaptations of intestinal macrophages to an antigen-rich environment. Seminars in immunology, 19(2), pp. 84-93. Philadelphia, Pa.: W.B. Saunders 10.1016/j.smim.2006.09.002

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Intestinal macrophages, preferentially located in the subepithelial lamina propria, represent in humans the largest pool of tissue macrophages. To comply with their main task, i.e. the efficient removal of microbes and particulate matter that might have gained access to the mucosa from the intestinal lumen while maintaining local tissue homeostasis, several phenotypic and functional adaptations evolved. Most notably, microbe-associated molecular pattern (MAMP) receptors, including the lipopolysaccharide receptors CD14 and TLR4, but also the Fc receptors for IgA and IgG are absent on most intestinal Mø. Here we review recent findings on the phenotypic and functional adaptations of intestinal Mø and their implications for the pathogenesis of inflammatory bowel diseases.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Schenk, Mirjam and Müller, Christoph

ISSN:

1044-5323

ISBN:

17055292

Publisher:

W.B. Saunders

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:48

Last Modified:

06 Dec 2013 13:42

Publisher DOI:

10.1016/j.smim.2006.09.002

PubMed ID:

17055292

Web of Science ID:

000247466100004

URI:

https://boris.unibe.ch/id/eprint/19924 (FactScience: 3002)

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