Rietmann, Stefan J.; Cochet-Faivre, Noëlle; Dropsy, Helene; Jagannathan, Vidhya; Chevallier, Lucie; Leeb, Tosso (2024). EDA Missense Variant in a Cat with X-Linked Hypohidrotic Ectodermal Dysplasia. Genes, 15(7) MDPI 10.3390/genes15070854
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Hypohidrotic ectodermal dysplasia is a developmental defect characterized by sparse or absent hair, missing or malformed teeth and defects in eccrine glands. Loss-of-function variants in the X-chromosomal EDA gene have been reported to cause hypohidrotic ectodermal dysplasia in humans, mice, dogs and cattle. We investigated a male cat exhibiting diffuse truncal alopecia with a completely absent undercoat. The cat lacked several teeth, and the remaining teeth had an abnormal conical shape. Whole-genome sequencing revealed a hemizygous missense variant in the EDA gene, XM_011291781.3:c.1042G>A or XP_011290083.1:p.(Ala348Thr). The predicted amino acid exchange is located in the C-terminal TNF signaling domain of the encoded ectodysplasin. The corresponding missense variant in the human EDA gene, p.Ala349Thr, has been reported as a recurring pathogenic variant in several human patients with X-linked hypohidrotic ectodermal dysplasia. The identified feline variant therefore represents the likely cause of the hypohidrotic ectodermal dysplasia in the investigated cat, and the genetic investigation confirmed the suspected clinical diagnosis. This is the first report of an EDA-related hypohidrotic ectodermal dysplasia in cats.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
05 Veterinary Medicine > Research Foci > DermFocus 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) |
UniBE Contributor: |
Rietmann, Stefan Jonas, Jagannathan, Vidya, Leeb, Tosso |
Subjects: |
500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture |
ISSN: |
2073-4425 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Jul 2024 10:43 |
Last Modified: |
07 Aug 2024 15:44 |
Publisher DOI: |
10.3390/genes15070854 |
PubMed ID: |
39062633 |
Uncontrolled Keywords: |
Felis catus WGS X-linked animal model dermatology development precision medicine skin |
BORIS DOI: |
10.48350/199324 |
URI: |
https://boris.unibe.ch/id/eprint/199324 |