Microcystic serous cystadenoma of the pancreas: a report of two cases with one of diffuse presentation

Tampi, Chandralekha; Mullerpatan, Prashant; Shah, Rajiv; Jagannath, Palepu; Zimmermann, Arthur (2006). Microcystic serous cystadenoma of the pancreas: a report of two cases with one of diffuse presentation. Pancreatology, 6(3), pp. 248-53. Amsterdam: Karger 10.1159/000092028

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Microcystic adenoma or serous cystadenoma is an uncommon tumor and accounts for 1-2% of the exocrine neoplasms of the pancreas. Usually unifocal, they present as single, large, well-demarcated multiloculated cystic tumors, ranging in size from 1 to 25 cm. Multifocal variants or diffuse serous cystadenomas are extremely rare. We present 2 cases of which 1 is a diffuse variant affecting the body, tail and part of the neck of the pancreas. In both the patients the tumors were detected incidentally. We highlight on the diffuse variant in view of its rarity and present a review of literature. In this case the entire body and tail of the pancreas was spongy replaced by multicystic lobules and hyalinized fibrocollagenous stroma. The cysts were lined by low cuboidal glycogen containing bland cells. Such a unique presentation wherein the entire body and tail of the pancreas is replaced with multiple cysts is a diffuse presentation of microcystic adenoma and a search through literature revealed only 7 such cases among the 15 cases with multifocal presentation reported.

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