The effect of gamma-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells

Samandari, Elika; Visarius, Theresa; Zingg, Jean-Marc; Azzi, Angelo (2006). The effect of gamma-tocopherol on proliferation, integrin expression, adhesion, and migration of human glioma cells. Biochemical and biophysical research communications, 342(4), pp. 1329-33. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2006.02.110

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The effect of vitamin E on proliferation, integrin expression, adhesion, and migration in human glioma cells has been studied. gamma-tocopherol at 50 microM concentration exerted more inhibitory effect than alpha-tocopherol at the same concentration on glioma cell proliferation. Integrin alpha5 and beta1 protein levels were increased upon both alpha- and gamma-tocopherol treatments. In parallel, an increase in the alpha5beta1 heterodimer cell surface expression was observed. The tocopherols inhibited glioma cell-binding to fibronectin where gamma-tocopherol treatment induced glioma cell migration. Taken together, the data reported here are consistent with the notion that the inhibition of glioma cell proliferation induced by tocopherols may be mediated, at least in part, by an increase in integrin alpha5 and beta1 expression. Cell adhesion is also negatively affected by tocopherols, despite a small increase in the surface appearance of the alpha5beta1 heterodimer. Cell migration is stimulated by gamma-tocopherol. It is concluded that alpha5 and beta1 integrin expression and surface appearance are not sufficient to explain all the observations and that other integrins or in general other factors may be associated with these events.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Zingg, Jean-Marc and Azzi, Angelo

ISSN:

0006-291X

ISBN:

16516856

Publisher:

Academic Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:49

Last Modified:

06 Dec 2013 13:43

Publisher DOI:

10.1016/j.bbrc.2006.02.110

PubMed ID:

16516856

Web of Science ID:

000236316100048

URI:

https://boris.unibe.ch/id/eprint/20380 (FactScience: 3668)

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