[Inherited alopecia X in Pomeranians]

Mausberg, E M; Drögemüller, Cord; Rüfenacht, S; Welle, Monika Maria; Roosje, Petra; Suter, M; Leeb, Tosso (2007). [Inherited alopecia X in Pomeranians]. DTW. Deutsche tierärztliche Wochenschrift, 114(4), pp. 129-34. Alfeld: Verlag M. & H. Schaper 10.2377/0341-6593-114-129

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Four male Pomeranians that showed alopecia with an age of onset between five months and eight years were investigated.The aim of the investigation was to clarify whether the affected dogs had alopecia X and whether their symptoms might be due to a hereditary defect.The four affected dogs showed hairless patches at the root of the tail, at the back, at the limbs from the thigh to the tarsus and at the abdomen. Within the hairless patches some islets with sparse hair were present. In hairless patches the skin was dark pigmented. Besides the alopecia and hyperpigmentation no other symptoms were found according to anamnestic and clinical examination. History, clinical examinations, laboratory diagnostics, and histopathology of skin biopsies allowed the diagnosis of alopecia X in three affected male dogs.The last one of the affected dogs additionally had slightly reduced thyroid hormone levels. Based on identical symptoms and the close relatedness of all four animals, it was assumed that the fourth affected dog also had alopecia X.The available data possibly indicate a monogenic autosomal dominant inheritance, however a recessive inheritance can not be excluded at this time.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Dermatology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
UniBE Contributor:	Mausberg, Eva-Maria, Drögemüller, Cord, Rüfenacht, Silvia, Welle, Monika Maria, Roosje Hasler, Pieternella, Suter, Maja, Leeb, Tosso
Subjects:	500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture
ISSN:	0341-6593
Publisher:	Verlag M. & H. Schaper
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:50
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.2377/0341-6593-114-129
PubMed ID:	17484499
Web of Science ID:	000246243900002
URI:	https://boris.unibe.ch/id/eprint/21157 (FactScience: 5122)