Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles

Bersinger, Nick A; Birkhäuser, Martin H; Wunder, Dorothea M (2006). Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles. Gynecological endocrinology, 22(9), pp. 479-83. London: Informa Healthcare 10.1080/09537100600931316

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Adiponectin (Acrp30) is an adipose tissue-derived protein whose serum concentrations, in contrast to leptin, are reported to be negatively correlated to body mass. In spite of the comparatively high circulating adiponectin concentrations, this protein has not been studied in the context of assisted reproduction to date. The aim of this preliminary project was thus to examine the potential of adiponectin to serve as a marker for fertility. We compared adiponectin levels in serum before and after controlled ovarian hyperstimulation, as well as in follicular fluid (FF), between two groups: those with successful outcome (clinical pregnancies) and those with implantation failure. In the former, adiponectin concentrations were higher than in the negative outcome group; this difference was statistically significant (p < 0.05) in serum on the day of oocyte pick-up (OPU) as well as two or three days before OPU, but not in FF or in serum at the beginning of the stimulation phase. This finding adds a new perspective to the suggested but still controversial reduction in FF leptin concentrations in the positive outcome group, and may become a useful tool for early prediction of success of in vitro fertilization treatment for a given patient.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Bersinger, Nick A.; Birkhäuser, Martin and Wunder, Dorothea

ISSN:

0951-3590

ISBN:

17071530

Publisher:

Informa Healthcare

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:50

Last Modified:

06 Dec 2013 13:44

Publisher DOI:

10.1080/09537100600931316

PubMed ID:

17071530

Web of Science ID:

000242222000002

URI:

https://boris.unibe.ch/id/eprint/21163 (FactScience: 5135)

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